Depression – Exciting Update!

Depression – Exciting Update!

Depression – Exciting Update!

All TreatGx users now have access to the updated Depression treatment algorithm! This comprehensive update includes many exciting enhancements that will help health care providers select the safest and most effective medications for their patients with depression.

Updates include:

✓  Personalized medication treatment options based on 3 different treatment strategies:

    • Initial treatment for depression
    • Switching between antidepressants
    • Adding augmentation or adjunctive therapy to current antidepressant

✓  Detailed side effect profiles for each antidepressant, including the frequency of occurrence of 10 of the most common or important adverse effects

✓  Ability to sort antidepressants by 10 different side effects, and listing options with a lower risk of causing the selected side effect first: lowest to highest risk:

    • Anticholinergic Effect
    • Sedation
    • Insomnia/Agitation
    • Weight Gain
    • Sexual Dysfunction
    • Nausea/Diarrhea
    • Orthostatic Hypotension
    • QTc Prolongation
    • Lethality in Overdose
    • Discontinuation Syndrome

✓  Detailed guidance for multiple strategies when switching from one antidepressant to another:

    • Taper-stop-start method
    • Cross-taper method
    • Washout periods

✓  Inclusion of the newest antidepressants on the market:

    • vilazodone (Viibryd)
    • levomilnacipran (Fetzima)
    • vortioxetine (Trintellix)

All medication doses in the depression algorithm are also personalized based on each patient’s genetics, kidney function, liver function, and other medications they may be taking.

One of the most significant challenges facing clinicians treating patients with depression is choosing the right medication for the right patient. Many people will try multiple medications that cause side effects or don’t improve their symptoms, before finding one that works for them. By tailoring medication treatment options and doses based on personalized information, TreatGx can help patients and their health care providers select the right medication for each patient. Now that TreatGx incorporates side effect profiles for each antidepressant, health care providers have more information at their fingertips to be able to discuss possible treatment options with their patients. Discussing potential side effects before starting a medication can help improve patient adherence and improves the chances that the medication will be tolerated.

Despite using all available information to personalize medication therapy, the first antidepressant that is prescribed may not work as desired. After an initial medication trial, TreatGx can help prescribers to guide their patients in safely switching to an alternate antidepressant or adding another medication as augmentation or adjunctive therapy. In addition to medications, psychotherapy and other non-pharmacological forms of treatment should be an integral part of therapy for those with depression.

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