Update: Smoking Cessation

Update: Smoking Cessation

The GenXys algorithm for Smoking Cessation has been updated and the new version is available to all TreatGx users.  To continue to provide effective medication options and strategies for smoking cessation, we reviewed and incorporated information from recent guidelines and papers.  These include the 2018 NICE guideline [1]and the 2018 American College of Cardiology expert consensus decision pathway [2].  We also included evidence from a recent Cochrane review on the use of different doses, durations and modes of nicotine replacement therapy for smoking cessation [3].   

Updates for the Smoking Cessation algorithm include: 

  • Recommendations for combination nicotine replacement therapy  
  • Updated target quit date strategies for varenicline 
  • Updated combination therapy information for varenicline and nicotine replacement therapy 


1.National Institute for Health and Care Excellence. Stop smoking interventions and services [NICE Guideline NG92]. 2018. https://www.nice.org.uk/guidance/ng92. 

2.Barua RS, Rigotti NA, Benowitz NL, et al. 2018 ACC Expert Consensus Decision Pathway on Tobacco Cessation Treatment: A Report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2018;72(25):3332-3365. 

3.Lindson N, Chepkin SC, Ye W, Fanshawe TR, Bullen C, Hartmann-Boyce J. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. The Cochrane database of systematic reviews. 2019;4(4):Cd013308. 

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