Update to Urinary Tract Infection & Pyelonephritis

17 May Update to Urinary Tract Infection & Pyelonephritis

To improve the usability of TreatGx, our Urinary Tract Infection treatment algorithm has been split into individual conditions: Urinary Tract Infection – Cystitis (Empiric therapy) and Urinary Tract Infection – Pyelonephritis (Empiric therapy). The greatest advantage to users is that there are many fewer questions to answer. The questions and information you enter for each of these conditions is more tailored to helping you select the safest and most effective medications – all part of helping get the right medication, right from the start.

Urinary Tract Infection – Cystitis (Empiric therapy)

The updated algorithm for cystitis provides a streamlined approach to medication options when selecting initial empirical therapy, and offers treatment options for both uncomplicated and complicated cystitis (lower urinary tract infection).

Urinary Tract Infection – Pyelonephritis (Empiric therapy)

The updated algorithm for cystitis provides a streamlined approach to medication options when selecting initial empirical therapy, and offers treatment options for both uncomplicated and complicated pyelonephritis (upper urinary tract infection).

These algorithms incorporate guidance from the Infections Diseases Society of America[1] and the European Association of Urology[2], as well as the New England Journal of Medicine[3], JAMA[4], and others

As always, both updates include the TreatGx standard of providing personalized dosing based on pharmacogenetics, kidney function, liver function, and drug interactions.

References

1. Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, Moran GJ, Nicolle LE, Raz R, Schaeffer AJ et al: International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011, 52(5):e103-120.
2. European Association of Urology: Guidelines on Urological Infections. In.: European Association of Urology; 2015.
3. Johnson JR, Russo TA: Acute Pyelonephritis in Adults. N Engl J Med 2018, 378(1):48-59.
4. Grigoryan L, Trautner BW, Gupta K: Diagnosis and management of urinary tract infections in the outpatient setting: a review. Jama 2014, 312(16):1677-1684.