What is pharmacogenetic testing?
Depending on your genetic makeup, some medications may work more effectively, less effectively or cause side effects for you. Our pharmacogenetic test detects genes that affect the way medications work within your body. Your genetic information can be used in TreatGx to help you and your health care professional select the best medication and dosing for you.
What unexpected things might I learn from pharmacogenetic testing?
GenXys testing has no incidental findings as the analysis is directed at the specific areas of the gene necessary to identify medication/gene interactions. Unlike other genetic tests, our test is designed to inform your medication choices. Our test will not inform you or your physician of diseases that you might get, for example cancer, vascular disease or Alzheimer’s.
How does TreatGx decision support work?
TreatGx generates medication options that are safe and effective for you by combining your genetics with up-to-date clinical evidence and information that you enter. TreatGx has been developed to facilitate the shared decision-making process between you and your health care professional. With TreatGx, you are able to access and update your personal information while viewing the effect this has on medication options, thereby strengthening your ability to make informed decisions about your health.
Log into your account and click the ‘Invite your clinician’ button. In this page, you can enter the email of the health care provider you would like to invite to view your results or find a clinician in our system. Once you find the name of your health care provider, click ‘+ Add’, and an invitation will be sent.
Can ancestry be identified with GenXys pharmacogenetic test?
No, GenXys pharmacogenetic testing has no incidental findings. Unlike other genetic tests, our test is designed only to inform your medication choices.
How do I give a sample?
Taking the test is easy! Once you receive your kit, follow the instructions and swab the inside of your mouth using the soft sponge. After registering your kit online, you mail it back to the GenXys lab using our prepaid return envelope.
Receiving and viewing your results
Your pharmacogenetic information is securely transferred to your account where you can generate your individualized medication options. Once you log into your account, you will use a series of drop down lists to enter information about your health status. This information may include your age, weight, liver and kidney function. After filling the required fields, TreatGX will display personalized treatment options specific to you and your condition.
How is this different than receiving a Genetic Report from other companies?
• Our pharmacogenetic test has no incidental findings. Unlike other genetic tests, our test is designed only to inform your medication choices
• Unlike other genetic tests, your report is translated into safe, effective and personalized medication options using TreatGx. For each drug option, TreatGx provides the appropriate dose based on your unique genetic profile together with other personal health information including other medications, renal/hepatic function, age, weight, and more.
• For severe ADR’s such as Stevens-Johnson syndrome, the TreatGx software will indicate that drug is not appropriate and provide an alternative.
• Conventional terminology of a patient being an “ultra-rapid metabolizer” may not be helpful. It is important to consider the mechanism of action, metabolism, and excretion of a drug in order to determine the appropriate adjustment.
For example: A CYP2D6 ultra-rapid metabolizer would metabolize codeine into an extremely large dose of morphine. This can result in adverse events including death. Alternatively, the same patient given nortriptyline would excrete most of the drug before reaching circulation. This can result in decreased response and prolong troubling symptoms.
What is DNA?
The human body is composed of trillions of cells, each with specific functions and roles. But how are these functions and roles coded? How does each cell know what to do?
Deoxyribonucleic acid (DNA) is a molecule found within the nucleus of all cells, packaged in chromosomes, and holding the information required by a cell to function. DNA is made up of four chemical bases called adenine (A), thymine (T), cytosine (C) and guanine (G) and their order within DNA provides instructions for making proteins. ..In addition to acting as a set of instructions, DNA also acts as the hereditary material that is passed down from parents to their children and is why children share similar traits with their parents.
Specific sequences of DNA, called genes, contain directions for how to build a particular protein. Proteins are responsible for nearly everything that happens in the body from determining eye color to breaking down medications. For example, a gene called CYP2D6 encodes for an enzyme called Cytochrome P450 2D6 which is responsible for the metabolism and elimination of approximately 25% of clinically used medications.
Each human cell contains billions of DNA bases and about 20,000 genes, which are collectively referred to as a genome. More than 99% of our genomes are the same, but variations do exist among people. The most common of these variations are called SNPs (Single Nucleotide Polymorphisms).
A SNP is the difference in a single DNA base at a particular location. For example, at a position of a gene the base C is the most common among a group of people, but in some individuals the position is occupied by base A. There are approximately 10 million SNPs in the human genome and most of these SNPs have no effect on the cell or on your health. However, a small number do affect the body and some SNPs affect how individuals respond to certain medications.
Another type of genetic variation is called CNV (Copy Number Variants), which occurs when the number of copies of a particular gene varies from one individual to the next.
List of Abbreviations used in the TreatGx software
Here are some common abbreviations used in the TreatGx software.
DS Double strength
EC Enteric coated
DPI Dry powder inhaler
pMDI Powdered metered dose inhaler
SC Subcutaneous injection
IV Intravenous injection
IM Intramuscular injection
IBW Ideal body weight
Shipping and ordering
Place an order online and you will receive our pharmacogenetic test and subscription to our medication decision support software. You will also receive a collection kit by mail with detailed instructions on how to collect a cheek swab sample and a prepaid addressed label for returning your sample to the GenXys laboratory. The sample collection kit must be used within three months from the date of purchase. The sample must be mailed to the laboratory within two weeks of sample collection.
Returning your sample to the lab
Once you receive your kit, follow the instructions and swab the inside of your mouth using the soft sponge. After collecting your sample, you mail it back to the GenXys lab using the prepaid return label in the kit.
How you can manage your health
TreatGx equips you and your health care professional with a software tool that can swiftly provide medication options based on your genetic profile, strengthening your ability to make informed decisions to improve your health.
Always consult your healthcare professional before starting, changing, or stopping medications.
Remember, medication is only one part of treatment; lifestyle changes including eating healthily and keeping active are vital aspects of managing your health.
If the laboratory processing fails, GenXys will offer to send you another kit at no extra charge. If you decline this option, you are entitled to a complete refund of the amount paid to GenXys, less shipping and handling.